Clinical Perspectives of Urocortin and Related Agents for the Treatment of Cardiovascular Disease

نویسندگان

  • Keiichi Ikeda
  • Kouki Fujioka
  • Yoshinobu Manome
  • Katsuyoshi Tojo
چکیده

The effects of corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF), on the cardiovascular system have been intensively researched since its discovery. Moreover, the actions of urocortin (Ucn) I on the cardiovascular system have also been intensively scrutinized following the cloning and identification of its receptor, CRF receptor type 2 (CRFR2), in peripheral tissues including the heart. Given the cardioprotective actions of CRFR2 ligands, the clinical potential of not only Ucn I but also Ucn II and III, which were later identified as more specific ligands for CRFR2, has received considerable attention from researchers. In addition, recent work has indicated that CRF type 1 receptor may be also involved in cardioprotection against ischemic/reperfusion injury. Here we provide a historical overview of research on Ucn I and related agents, their effects on the cardiovascular system, and the clinical potential of the use of such agents to treat cardiovascular diseases.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hematopoietic stem cell transplant therapy, clinical trials, complications, and quality of life for patients with Sickle cell anemia: Clinical potential and future perspectives

Background: Sickle cell anemia (SCA) is an inherited monogenic disorder. The clinical symptoms of SCA are protean, including vaso-occlusion, hemolysis, early stroke, leg ulcers, multi-organ failure, and increased risk of premature death. Hematopoietic stem cell transplantation is the only treatment identified to reduce SCA-related organ damage. Unfortunately, graft rejection is a significant im...

متن کامل

Relationship between Spexin Neuropeptide and Cardiovascular Risk Factors in Children and Adolescents: A Systematic Review

Introduction: Spexin, a novel neuropeptide with diverse physiological functions, can be a cardiovascular disease risk assessment biomarker. This study investigated the association between serum spexin concentration and cardiovascular risk factors in children and adolescents. Materials and Methods: A search was conducted to collect studies between January 2007 and March 2021 in the PubMed, Embas...

متن کامل

Urocortin Expression in Endometriosis: A Systematic Review

Urocortin is a neuropeptide belonging to the corticotrophin-releasing hormone family and is expressed by eutopic and ectopic human endometrium and the last years is investigated in the field of endometriosis. The objective of this systematic review is to accumulate current evidence related to the expression of urocortin in tissue and blood samples of patients suffering from endometriosis. Liter...

متن کامل

The effects of cinnamon on risk factors of cardiovascular disease

Introduction: Herbal medicine is being considered today due to the side effects and high prices of chemical medicines. Cinnamon appears to be effective in the prevention and treatment of a variety of diseases, both as a food spice and in traditional medicine. We attempted to collect the effects of cinnamon on the occurrence of cardiovascular disorders and their related parameters in this review...

متن کامل

Apical Hypertrophic Cardiomyopathy in a Case with Chest Pain and Family History of Sudden Cardiac Death: A Case Report

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease, which is caused by a multitude of mutations in genes encoding proteins of the cardiac sarcomere (1). Apical hypertrophic cardiomyopathy (AHCM) is an uncommon type of HCM. The sudden cardiac death is less likely to occur in the patients inflicted with AHCM (2). Herein, we presented the case of a 29-year-old man ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2012  شماره 

صفحات  -

تاریخ انتشار 2012